GUTS Shiny Application

This web page allows interactive simulations of the General Unified Threshold model of Survival (GUTS) based on the scaled internal concentration either with a constant or a time-variable exposure concentration profile. The two reduced (RED) versions are implemented: the stochastic death version (GUTS-RED-SD) and the individual tolerance version (GUTS-RED-IT). See [1, 2] for details.


Input your concentration profile

Please upload a two-column file in text format. Default is comma-separated values but other separators can be chosen. Columns with headers must be the followings:
1. The time points at which you measured concentrations (header = 'time');
2. The measured concentrations (header = 'conc').
In case of constant exposure, the second column must be filled-in with the same value whatever the time point.

Here are four example files to test the GUTS-ShinyApp:

Model and parameters


Parameters values

Parameters values

Parameters values

Margin of Safety

Predictions over time


Build a report



1. Jager T, Albert C, Preuss T, Ashauer R. 2011. General Unified Threshold Model of Survival-a Toxicokinetic-Toxicodynamic Framework for Ecotoxicology. Environ. Sci. Technol. 45:2529–2540.
2. Ashauer R, Albert C, Augustine S, Cedergreen N, Charles S, Ducrot V, Focks A, Gabsi F, Gergs A, Goussen B, Jager T, Kramer NI, Nyman A-M, Poulsen V, Reichenberger S, Schäfer RB, Van den Brink PJ, Veltman K, Vogel S, Zimmer EI, Preuss TG. 2016. Modelling survival: exposure pattern, species sensitivity and uncertainty. Nat. Sci. Rep. 6:29178.


Sandrine CHARLES, professor at University Lyon 1
Virgile BAUDROT, CNRS post-doc
Maud REPELLIN, bachelor student at University Lyon 1
Aurélie SIBERCHICOT, engineer at University Lyon 1