GUTS Shiny Application



This web page allows interactive simulations of the General Unified Threshold model of Survival (GUTS) based on the scaled internal concentration either with a constant or a time-variable exposure concentration profile. The two reduced (RED) versions are implemented: the stochastic death version (GUTS-RED-SD) and the individual tolerance version (GUTS-RED-IT). See [1, 2] for details.

Contact: sandrine.charles@univ-lyon1.fr

Input your concentration profile

Please upload a two-column file in text format. Default is comma-separated values but other separators can be chosen. Columns with headers must be the followings:
1. The time points at which you measured concentrations (header = 'time');
2. The measured concentrations (header = 'conc').
In case of constant exposure, the second column must be filled-in with the same value whatever the time point.

Here are four example files to test the GUTS-ShinyApp:
conc-cst.csv
conc-var-01.csv
conc-var-02.csv
FOCUS-SW.csv

Model parameters

Please choose a value for parameter hb ([time]-1) which is the background mortality of your species, then a value for the dominant rate constant kd ([time]-1) of the TK part of the GUTS model.
Please choose GUTS-RED-SD parameters, that is the threshold concentration zw ([concentration]) for all individuals corresponding to the no effect concentration for the chemical under consideration and the killing rate bw ([concentration] -1.[time]-1)
Please choose GUTS-RED-IT parameters, that is the median mw ([concentration]) of the threshold concentration distribution among individuals (log-logistic law) and the shape of this distribution, β (dimensionless).

Margin of Safety


Predictions over time




Downloads


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References

1. Jager T, Albert C, Preuss T, Ashauer R. 2011. General Unified Threshold Model of Survival-a Toxicokinetic-Toxicodynamic Framework for Ecotoxicology. Environ. Sci. Technol. 45:2529–2540.
2. Ashauer R, Albert C, Augustine S, Cedergreen N, Charles S, Ducrot V, Focks A, Gabsi F, Gergs A, Goussen B, Jager T, Kramer NI, Nyman A-M, Poulsen V, Reichenberger S, Schäfer RB, Van den Brink PJ, Veltman K, Vogel S, Zimmer EI, Preuss TG. 2016. Modelling survival: exposure pattern, species sensitivity and uncertainty. Nat. Sci. Rep. 6:29178.

Contributors

Sandrine CHARLES, professor at University Lyon 1
Virgile BAUDROT, CNRS post-doc
Maud REPELLIN, bachelor student at University Lyon 1
Aurélie SIBERCHICOT, engineer at University Lyon 1