GUTS Shiny Application



This web page allows interactive simulations of the General Unified Threshold model of Survival (GUTS) based on the scaled internal concentration either with a constant or a time-variable exposure concentration profile. The two reduced (RED) versions are implemented: the stochastic death version (GUTS-RED-SD) and the individual tolerance version (GUTS-RED-IT). See [ 1 , 2 ] for details.

Contact: sandrine.charles@univ-lyon1.fr

Input your concentration profile

Please upload a two-column file in text format. Default is comma-separated values but other separators can be chosen. Columns with headers must be the followings:
1. The time points at which you measured concentrations (header = 'time');
2. The measured concentrations (header = 'conc').
In case of constant exposure, the second column must be filled-in with the same value whatever the time point.

Here are four example files to test the GUTS-ShinyApp:
conc-cst.csv
conc-var-01.csv
conc-var-02.csv
FOCUS-SW.csv

Model and parameters

Models




Parameters values










Be carefull, with distributed parameters, calculations may be long. Be patient!

Parameters values

The file that contains the distributed parameters must be with 4 columns named "hb", "kd", "zw" and "bw", with a tab as separator and a dot for decimals.
Such a file may come from a fit with the R package morse or having been saved after running MOSAIC_GUTS-fit.
Here is an example file for your convenience: SD_mcmc.txt







Be carefull, with distributed parameters, calculations may be long. Be patient!

Parameters values

The file that contains the distributed parameters must be with 4 columns named "hb", "kd", "mw" and "beta", with a tab as separator and a dot for decimals.
Such a file may come from a fit with the R package morse or having been saved after running MOSAIC_GUTS-fit.
Here is an example file for your convenience: IT_mcmc.txt




Margin of Safety

The concept of 'margin-of-safety' corresponds to the concept of 'x% Lethal Profile' or LPx as emphasized by the recent Scientific Opinion from EFSA [ 3 ].






Click this button each time you update a setting above

Calculations can take a long time, be patient !

Predictions over time



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References

1. Jager T, Albert C, Preuss T, Ashauer R. 2011. General Unified Threshold Model of Survival-a Toxicokinetic-Toxicodynamic Framework for Ecotoxicology. Environ. Sci. Technol. 45:2529–2540.
2. Ashauer R, Albert C, Augustine S, Cedergreen N, Charles S, Ducrot V, Focks A, Gabsi F, Gergs A, Goussen B, Jager T, Kramer NI, Nyman A-M, Poulsen V, Reichenberger S, Schäfer RB, Van den Brink PJ, Veltman K, Vogel S, Zimmer EI, Preuss TG. 2016. Modelling survival: exposure pattern, species sensitivity and uncertainty. Nat. Sci. Rep. 6:29178.
3. EFSA PPR Panel. 2018. Scientific Opinion on the state of the art of Toxicokinetic/Toxicodynamic (TKTD) effect models for regulatory risk assessment of pesticides for aquatic organisms. EFSA Journal. 16: 5377. Available at https://www.efsa.europa.eu/en/efsajournal/pub/5377

Contributors

Sandrine CHARLES, professor at University Lyon 1
Virgile BAUDROT, CNRS post-doc
Maud REPELLIN, bachelor student at University Lyon 1
Aurélie SIBERCHICOT, engineer at University Lyon 1