GUTS-ShinyApp

Contact

sandrine.charles@univ-lyon1.fr
This web page allows interactive simulations of the General Unified Threshold model for Survival (GUTS) based on the scaled internal concentration (SIC) either with a constant or a time-variable exposure concentration profile.
The two variants are implemented: the stochastic death variant (GUTS-SIC-SD) and the individual tolerance variant (GUTS-SIC-IT). See [1, 2] for details.

Input your concentration profile

Please upload a two-column file in text format. Default is comma-separated values but other separators can be chosen. Columns with headers must be the followings:
1. The time points at which you measured concentrations (header = 'time');
2. The measured concentrations (header = 'conc').
In case of constant exposure, the second column must be filled-in with the same value whatever the time point.

Model parameters

Please choose a value for parameter hb ([time]-1 ) which is the background mortality of your species, then a value for the dominant rate constant kd ([time]-1) of the TK part of the GUTS model.
Please choose GUTS-SIC-SD parameters, that is the threshold concentration Z ([concentration]) for all individuals corresponding to the no effect concentration for the chemical under consideration and the killing rate kk ([concentration] -1.[time]-1)
Please choose GUTS-SIC-IT parameters, that is the median α ([concentration]) of the threshold concentration distribution among individuals (log-logistic law) and the shape of this distribution, β (dimensionless).

Margin of Safety

Please choose a multiplication to apply to your exposure profile.

Model simulations

Download

Download Plot
Download Profiles Data

References

1. Jager T, Albert C, Preuss T, Ashauer R. 2011. General Unified Threshold Model of Survival-a Toxicokinetic-Toxicodynamic Framework for Ecotoxicology. Environ. Sci. Technol. 45:2529–2540.
2. Ashauer R, Albert C, Augustine S, Cedergreen N, Charles S, Ducrot V, Focks A, Gabsi F, Gergs A, Goussen B, Jager T, Kramer NI, Nyman A-M, Poulsen V, Reichenberger S, Schäfer RB, Van den Brink PJ, Veltman K, Vogel S, Zimmer EI, Preuss TG. 2016. Modelling survival: exposure pattern, species sensitivity and uncertainty. Nat. Sci. Rep. 6:29178.

Contributors

Sandrine CHARLES, professor at University Lyon 1
Virgile BAUDROT, CNRS post-doc
Maud REPELLIN, bachelor student at University Lyon 1