This web page allows interactive simulations of the General Unified Threshold model for Survival (GUTS) based on the scaled internal concentration (SIC) either with a constant or a time-variable exposure concentration profile.
The two variants are implemented: the stochastic death variant (GUTS-SIC-SD) and the individual tolerance variant (GUTS-SIC-IT). See [1, 2] for details.
Input your concentration profile
Please upload a two-column file in text format. Default is comma-separated values but other separators can be chosen. Columns with headers must be the followings:
1. The time points at which you measured concentrations (header = 'time');
2. The measured concentrations (header = 'conc').
In case of constant exposure, the second column must be filled-in with the same value whatever the time point.
Please choose a value for parameter
) which is the background mortality of your species, then a value for the dominant rate constant
of the TK part of the GUTS model.
Please choose GUTS-SIC-SD parameters, that is the threshold concentration Z ([concentration]) for all individuals corresponding to the no effect concentration for the chemical under consideration and the killing rate
Please choose GUTS-SIC-IT parameters, that is the median
([concentration]) of the threshold concentration distribution among individuals (log-logistic law) and the shape of this distribution,
Margin of Safety
Please choose a multiplication to apply to your exposure profile.