Welcome to the DRomicsInterpreter-shiny application
A second workflow for interpretation in light of a biological annotation

DRomicsInterpreter-shiny application runs on the shiny server of the LBBE with the develoment version of the DRomics package (available on Github ).

DRomics is also an R package, available on CRAN and on this web page .

You can find help about the DRomicsInterpreter-shiny application and the DRomics package in a vignette and a cheat sheet .

Citation and publications

If you use Dromics Shiny App, you should cite:

Larras F, Billoir E, Baillard V, Siberchicot A, Scholz S, Wubet T, Tarkka M, Schmitt-Jansen M and Delignette-Muller ML (2018).
DRomics: a turnkey tool to support the use of the dose-response framework for omics data in ecological risk assessment.
Environmental Science & Technology. https://doi.org/10.1021/acs.est.8b04752

You can freely find this article at: https://hal.archives-ouvertes.fr/hal-02309919

You can also look at the following citation for a complete example of use:

Larras F, Billoir E, Scholz S, Tarkka M, Wubet T, Delignette-Muller ML, Schmitt-Jansen M (2020).
A multi-omics concentration-response framework uncovers novel understanding of triclosan effects in the chlorophyte Scenedesmus vacuolatus.
Journal of Hazardous Materials. https://doi.org/10.1016/j.jhazmat.2020.122727

Contacts and authors

If you have any need that is not yet covered, any feedback on the package / Shiny app, or any training needs, feel free to email us at dromics@univ-lyon1.fr .

Issues can be reported on https://github.com/aursiber/DRomics/issues .

Elise Billoir - elise.billoir@univ-lorraine.fr - Laboratoire Interdisciplinaire des Environnements Continentaux - Université de Lorraine - Metz - France

Marie-Laure Delignette-Muller - marielaure.delignettemuller@vetagro-sup.fr - Laboratoire de Biométrie et Biologie Evolutive - VetAgro Sup - Lyon - France

Floriane Larras - floriane.larras@inrae.fr - Delegation for scientific expertise, foresight and advanced studies (DEPE) - INRAE - Paris - France

Mechthild Schmitt-Jansen - mechthild.schmitt@ufz.de - Department of Bioanalytical Ecotoxicology - Helmholtz Center for Environmental Research GmbH - Leipzig - Germany

Aurélie Siberchicot - aurelie.siberchicot@univ-lyon1.fr - Laboratoire de Biométrie et Biologie Evolutive - Université Lyon 1 - Lyon - France

Import and merge of DRomics results and annotation data

Structure of the data frame merged and combined


First 3 lines of each experimental level in the data frame merged and combined

Trend and sensitivity plots

Selection of annotation groups to plot  

Structure of the data frame merged and combined

              Download Data

BMD plots (with and without gradient)

Curves plot


To see what more you can do using the R package, we recommend you to consult the vignette and the cheat sheet of the package.

Download R Code