This web page allows interactive simulations of the General Unified Threshold model of Survival (GUTS)
based on the scaled internal concentration either with a constant or a time-variable exposure concentration profile.
The two reduced (RED) versions are implemented: the stochastic death version (GUTS-RED-SD) and the individual tolerance version (GUTS-RED-IT).
See [1 , 2] for details.

All calculations can be run directly within the R software by using package
morse; a tutorial is available
here.

Please upload at least a two-column file in .txt or .csv format. The correct separator has to be chosen. Columns with headers must be the followings:

- The time points at which you measured concentrations (header =
**'time'**) - The measured concentrations within the organisms, must be in
*μg.g*(header =^{-1}**'conc'**). In case of constant exposure, the second column must be filled-in with the same value whatever the time point.

Be careful, with distributed parameters, calculations may be long. Be patient!

Such a file may come from a fit with the R package morse or have been saved after running MOSAIC_GUTS-fit [ 5 ].

Here is an example file for your convenience: mcmc-ringtest-B-SD.txt

Be careful, with distributed parameters, calculations may be long. Be patient!

Such a file may come from a fit with the R package morse or have been saved after running MOSAIC_GUTS-fit. [ 5 ].

Here is an example file for your convenience: mcmc-ringtest-B-IT.txt

Calculations can take a long time, be patient!

Calculations can take a long time, be patient!

Download

Download

Supplementary files required to run the R script:

MOSAIC_guts-predict_sources.RgutsRedIT.dll

gutsRedIT.so

gutsRedSD.dll

gutsRedSD.so

Virgile Baudrot, Scientific Researcher

Aurélie Siberchicot, Engineer at University Lyon 1

Maud Repellin, bachelor student at University Lyon 1